The involvement of microRNAs in Type 2 diabetes

T2D (Type 2 diabetes mellitus) is a major health issue that has reached epidemic status worldwide T2D is a progressive metabolic disorder characterized by reduced insulin sensitivity insulin resistance and pancreatic beta cell dysfunction Improper treatment of TD2 can lead to severe complications such as heart disease stroke kidney failure blindness and nerve damage The aetiology and molecular mechanisnns of T2D are not fully understood but compelling evidence points to a link between T2D obesity dyslipidaemia and insulin resistance Although T2D seems to be strongly linked to environmental factors such as nutrition and lifestyle studies have shown that genetic factors such as polymorphisms associated with metabolic genes imprinting fetal programming and miRNA (microRNA) expression could also contribute to the development of this disease miRNAs are small 22-25 nt long untranslated RNAs that negatively regulate the translation of mRNAs miRNAs are involved in a large number of biological functions such as development metabolism immunity and diseases such as cancer cardiovascular diseases and diabetes The present review examines the various miRNAs that have been identified as being potentially involved in T2D focusing on the insulin sensitive organs white adipose tissue liver skeletal muscle and the insulin producing pancreatic beta cells