期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1270-1274出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381270
关键词
calcium signalling; chemotaxis; fertilization; flagellum; sea-urchin sperm; sperm motility
资金
- Consejo Nacional de Cienca y Tecnologia (CONACyT) [56660, 49113]
- National Institutes of Health [R01 HD038082-07A1]
- Programa de Apoyo a Proyectas de Investigacion e Innovacion Technologica (PAPIIT) [IN211907, IN211809, IN109210]
- Wellcome Trust
Sperm chemotaxis is a long-term puzzle and most of our knowledge comes from studying marine animals that are external fertilizers. Sperm are attracted by diffusible chemical factors (chemoattractants) released from the egg which redirect their swimming paths towards their source. This redirection is driven by increases in flagellar curvature that correlate with transient flagellar Ca2+ increases. Recent experimental and modelling results provide insights into the signal flow underlying the translation of an external chemical gradient into an intracellular molecular and motor response. A fundamental element of sea-urchin sperm chemotaxis lies in the ability of these cells to suppress Ca2+-mediated increases in flagellar curvature while experiencing an increasing chemoattractant gradient. The article considers this new evidence and summarizes the known underlying cellular mechanisms and behavioural strategies that sperm use to locate and fertilize the oocyte.
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