期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 104-109出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0380104
关键词
budding yeast; checkpoint; DNA damage; proliferating-cell nuclear antigen (PCNA); replication; ubiquitin-processing protease (UBP)
Eukaryotes ubiquitylate the replication factor PCNA (proliferating-cell nuclear antigen) so that it tolerates DNA damage. Although, in the last few years, the understanding of the evolutionarily conserved mechanism of ubiquitylation of PCNA, and its crucial role in DNA damage tolerance, has progressed impressively, little is known about the deubiquitylation of this sliding clamp in most organisms. in the present review, we will discuss potential molecular mechanisms regulating PCNA deubiquitylation in yeast.
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