期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 217-222出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0380217
关键词
cyclin D1; nuclear factor kappa B (NF-kappa B); RNA processing; Smad nuclear interacting protein 1 (SNIP1); transcription
资金
- Cancer Research UK Funding Source: Medline
Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. in different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-kappa B (nuclear factor kappa B)/IKK [I kappa B (inhibitor of NF-kappa B) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.
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