期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 1007-1013出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0371007
关键词
dynamic instability; kinesin-13; microtubule-associated protein; microtubule dynamics; microtubule assembly and disassembly regulation; tau protein
资金
- Scientific Research NWO Vici and Open programme
- Marie Curie Cancer Cafe
Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differentiation processes. While we only begin to appreciate how the concerted action of MT stabilizers and destabilizers shapes different MT patterns, a clear picture of how individual factors affect the MT structure is emerging. in this paper, we review the current knowledge about proteins that modulate MT dynamic instability.
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