期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 213-216出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0370213
关键词
amino acid sensing; autophagy; protein kinase; mammalian target of rapamycin (mTOR); therapeutic agent
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Cancer Research UK [C19591/A6181, A9093, A6181, C7713/A6174, A6174] Funding Source: Medline
mTOR (mammalian target Of rapamycin) is a highly conserved serine/threonine Protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors (in particular insulin and insulin-like growth factors), nutrients and cellular stresses, some of the mechanisms involved are still poorly understood. Recent work has implicated mTOR in a variety of important human pathologies, including cancer, Type 2 diabetes and neurodegenerative disorders, heightening interest and accelerating progress in dissecting out the control and functions of mTOR.
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