期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 173-177出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0370173
关键词
epidermal growth factor receptor (EGFR); endosomal sorting complex required for transport (ESCRT); multivesicular body (MVB); phosphoinositide 3-kinase (PI3K); protein tyrosine phosphatase 1B (PTP1B)
资金
- Biotechnology and Biological Sciences Research Council [BB/D011841] Funding Source: Medline
- Cancer Research UK [C20675] Funding Source: Medline
- Wellcome Trust [078304] Funding Source: Medline
Activated EGFR (epidermal growth factor receptor) undergoes ESCRT (endosomal sorting complex required for transport)-mediated sorting on to the intraluminal vesicles of MVBs (multivesicular bodies) before degradation in the lysosome. Sorting of endocytosed EGFR on to the intraluminal vesicles of MVBs removes the catalytic domain of the EGFR from the cytoplasm, resulting in termination of receptor signalling. The formation of intraluminal vesicles that contain EGFR is promoted by EGF stimulation in a mechanism that depends on the EGFR substrate, annexin 1. Signalling from endocytosed EGFR is also subject to down-regulation through receptor dephosphorylation by PTPs (protein tyrosine phosphatases), such as 113718, an enzyme thought to reside on the ER (endoplasmic reticulum). in the present paper, we review how the phosphorylation state of components of the MVB sorting machinery, as well as the EGFR may play a critical role in regulating EGFR sorting and signalling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据