期刊
NATURE CELL BIOLOGY
卷 3, 期 5, 页码 E112-E113出版社
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35074634
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Expression of the cell cycle inhibitor p15(INK4b) is suppressed by the Myc oncoprotein and induced by transforming growth factor-beta (TGF-beta). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-beta -activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.
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