期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 90, 期 5, 页码 1631-1638出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jappl.2001.90.5.1631
关键词
maturation; respiratory system impedance; forced oscillations; lung structure; morphometry; hyperresponsiveness
资金
- NHLBI NIH HHS [HL-03784] Funding Source: Medline
The purpose of the present study was to establish how the dependence of respiratory mechanics on lung inflation changes during development. We studied seven groups of rats from 10 days to 3 mo of age at five levels of positive end-expiratory pressure (PEEP) from 0 to 7 hPa (1 hPa = 0.1 kPa approximate to 1 cmH(2)O). At each PEEP level, we measured respiratory system resistance and elastance at both 0.9 and 4.8 Hz to partition the mechanical properties into its airway and tissue components. Elastance increased more rapidly with PEEP in the younger animals, which we interpret as reflecting a more pronounced strain stiffening of the younger parenchyma. However, the decrease in airway resistance with PEEP was more pronounced in the older animals. Morphometric analysis showed that mean tissue density decreased and total alveolar surface area increased with age. Our data suggest that the mechanical interdependence between airways and parenchyma is weaker in very young animals compared with mature animals. This may play a role in the hyperresponsiveness of immaturity.
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