期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 1050-1055出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0371050
关键词
aging; anti-aging drug; lipid droplet; longevity; necrosis; peroxisome
资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Concordia University Research Chair Fund
Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. it has become clear that the LDs-confined deposition and lipolytic degradation of neutral lipids define longevity in multicellular eukaryotic organisms and yeast. We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast.
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