期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 36, 期 -, 页码 701-707出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0360701
关键词
eukaryotic initiation factor 4E-binding protein (4E-BP); eukaryotic initiation factor 4F (elF4F); herpesvirus; infected cell protein 27 (ICP27); translational regulation
资金
- MRC (Medical Research Council)
- MRC Senior Non-Clinical Research
- MRC [G117/564, G9826324] Funding Source: UKRI
- Medical Research Council [G9826324, G117/564] Funding Source: researchfish
Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour viral protein synthesis. Consequently, the study of viral translation has been a powerful tool for illuminating many aspects of cellular translational control. Although much work to date has focused on translational regulation by RNA viruses, DNA viruses have also evolved complex mechanisms to regulate protein synthesis. Here we summarize work on a large family of DNA viruses, the Herpesviridae, which have evolved mechanisms to sustain efficient cap-dependent translation and to regulate the translation of specific viral mRNAs.
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