期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 36, 期 -, 页码 1201-1205出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0361201
关键词
acute myeloid leukaemia (AML); all-trans retinoic acid (ATRA); CCAAT/enhancer-binding protein (C/EBP); haemopoiesis; microRNA (miRNA); myelopoiesis
资金
- AIRC (Associazione Italiana per la Ricerca sul Cancro) and AIRC-ROC (Rome Oncogenic Centre)
- Sixth Research Framework Programme of the European Union
- Project RIGHT (RNA Interference Technology as Human Therapeutic Tool) [LSHB-CT-2004 005276]
- SIROCCO (Silencing RNAs: Organisers and Coordinators of Complexity in Eukaryotic Organisms) [037900]
- PRIN (Progetti di Ricerca di Interesse Nazionale)
All types of blood cell of the body are continuously produced by rare pluripotent self-renewing HSCs (haemopoietic stem cells) by a process known as haemopoiesis. This process provides a valuable model for examining how genetic programmes involved in cell differentiation are established, and also how cell-fate specification is altered in leukaemia. Here, we describe examples of how miRNAs (microRNAs) can influence myelopoiesis and how the identification of their target mRNAs has contributed to the understanding of the molecular networks involved in the alternative control between cell growth and differentiation. Ectopic expression and knockdown of specific miRNAs have provided powerful molecular tools able to control the switch between proliferation and differentiation, therefore providing new therapeutic tools for interfering with tumorigenesis.
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