期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 36, 期 -, 页码 935-940出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0360935
关键词
adipose tissue; expandability; fat storage; insulin resistance; metabolism; obesity
资金
- Biotechnology and Biological Sciences Research Council [BB/E011950/1] Funding Source: researchfish
- Medical Research Council [G0400192] Funding Source: researchfish
- BBSRC [BB/E011950/1] Funding Source: UKRI
- MRC [G0400192] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E011950/1] Funding Source: Medline
- Medical Research Council [G0400192] Funding Source: Medline
The prevalence of obesity is increasing and with it the prevalence of associated metabolic complications. Precisely how obesity results in metabolic disturbances remains unclear. in the face of persistent positive caloric balance, it has been postulated that the capacity of adipose tissue to safely store fat may be vital. This paper explores some of the evidence suggesting that the risk of developing metabolic disturbances is not related to how much fat an individual has, but how well their fat can expand to accommodate the caloric excess. if this is true, the metabolic consequences of obesity may arise from the inability to become more obese.
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