期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 36, 期 -, 页码 46-50出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0360046
关键词
computational chemistry; fluorescence resonance energy transfer (FRET); fluorescence-based molecular probe; molecular dynamics simulation; single nucleotide polymorphism (SNP); structure-based design of molecular diagnostics
The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeaconS(TM), split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems. Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield.
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