相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit
A. D. Mancini et al.
DIABETES OBESITY & METABOLISM (2015)
GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
Maria Hauge et al.
MOLECULAR METABOLISM (2015)
Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40
Jing Qian et al.
CELLULAR SIGNALLING (2014)
Recent developments in biased agonism
James W. Wisler et al.
CURRENT OPINION IN CELL BIOLOGY (2014)
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
Magalie A. Ravier et al.
DIABETOLOGIA (2014)
Allosteric Modulation of M1 Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking
Holly R. Yeatman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
Ankita Srivastava et al.
NATURE (2014)
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients
Venkategowda Sunil et al.
BMC PHARMACOLOGY & TOXICOLOGY (2014)
Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans
Robert Wagner et al.
DIABETES (2013)
OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact
Terry Kenakin et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1
Chiori Yabuki et al.
PLOS ONE (2013)
The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
Arturo D. Mancini et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
AMG 837: A potent, orally bioavailable GPR40 agonist
Jonathan B. Houze et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Restructuring G-Protein-Coupled Receptor Activation
Martin Audet et al.
CELL (2012)
A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes
E. Leifke et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands
Colette Denis et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
M. Ferdaoussi et al.
DIABETOLOGIA (2012)
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
Charles F. Burant et al.
LANCET (2012)
Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor
Daniel C. -H. Lin et al.
MOLECULAR PHARMACOLOGY (2012)
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
Brady K Atwood et al.
BMC GENOMICS (2011)
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
Arun K. Shukla et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells
Julie Quoyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
Kok Choi Kong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist
Nobuyuki Negoro et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
Melkam Kebede et al.
DIABETES (2008)
β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells
Noriyuki Sonoda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification of residues important for agonist recognition and activation in GPR40
Chi Shing Sum et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
β-arrestin-biased ligands at seven-transmembrane receptors
Jonathan D. Violin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
Martin G. Latour et al.
DIABETES (2007)
Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
Celine Gales et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Reduction in voltage-gated K+ currents in primary cultured rat pancreatic β-cells by linoleic acids
DD Feng et al.
ENDOCRINOLOGY (2006)
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
DK Hagman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Role of GPR40 in fatty acid action on the β cell line INS-1E
H Shapiro et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
HJ Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
CP Briscoe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Y Itoh et al.
NATURE (2003)
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
K Maedler et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)