Memory CD8+ T cell differentiation:: initial antigen encounter triggers a developmental program in naive cells

The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naive CD8(+)T cells become committed to dividing at least seven times and differentiating into effector and memory cells. Once the parental naive CD8(+) T cell had been activated, this developmental process could not be interrupted and the daughter cells continued to divide and differentiate in the absence of further antigenic stimulation. These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8(+) T cell formation.