期刊
BIOCHEMICAL PHARMACOLOGY
卷 86, 期 1, 页码 56-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2013.03.021
关键词
Cholesterol; Sterol; SBGN; Metabolic network; Pathway map
资金
- BBSRC [BB/I001735/1]
- EPSRC [D019621]
- Wellcome Trust [WT066784]
- BBSRC [BB/D019621/1, BB/I001735/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I001735/1, BB/D019621/1] Funding Source: researchfish
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. (C) 2013 Elsevier Inc. All rights reserved.
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