期刊
BIOCHEMICAL PHARMACOLOGY
卷 86, 期 9, 页码 1239-1247出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2013.08.007
关键词
Natural compounds; Cancer hallmarks; Inflammation signaling; Cell cycle; Cell death; Immune system; Tumor microenvironment
资金
- Televie grants (Fonds National de la Recherche Scientifique, Belgium)
- European Community [215009]
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg asbl
- Een Haerz fir Kriibskrank Kanner association
- Action Lions Vaincre le Cancer Luxembourg
- Fonds National de la Recherche Luxembourg
- Televie Luxembourg
- Foundation for Scientific Cooperation Germany
- Foundation for Scientific Cooperation Luxemburg
- National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant [2012-0001184]
- Seoul National University Research grant
- Research Settlement Fund for the new faculty of SNU
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summarize impact and effect of selected purified active natural compounds from plants used in European medieval medicinal traditions on cancer hallmarks and enabling characteristics identified by Hanahan and Weinberg. The aim of this commentary is to discuss the pharmacological effect of pure compounds originally discovered in plants with therapeutic medieval use. Whereas many reviews deal with Ayurvedic traditions and traditional Chinese medicine, to our knowledge, the molecular basis of European medieval medicinal approaches are much less documented. (C) 2013 Elsevier Inc. All rights reserved.
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