期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 23, 期 4, 页码 317-328出版社
TAYLOR & FRANCIS INC
DOI: 10.1081/CEH-100102670
关键词
SHR; WKY; flow shear rate; nitric oxide; resistance vessels
Alterations of blood rheological properties can affect blood flow shear rates and therefore alter changes in the interactions between blood and vascular wall components during the development of hypertension. This study was done to evaluate alterations of blood flow shear rates in resistance vessels during the development of genetic hypertension in rats. In the current study, measurements were carried out on spontaneously hypertensive rats (SHR) during an early (3 weeks of age) and an established stage (12 weeks of age) of hypertension development. Age matched normotensive Wistar Kyoto (WKY) rats were used as controls. Intravital television microscopy was used to quantitate blood flow shear rates in first-(1A), second-(2A) and third-order (3A) arterioles of the cremaster muscle. In the young SHRs mean arterial blood pressure was not different from age matched WKY rats, but there was a significant increase of shear rate values in all observed (1A, 2A, 3A) arterioles of SHRs. However, shear rate values were significantly less in arterioles (1A, 2A, 3A) of SHRs with an established hyper tension compared to the 3-week-old SHR group. We conclude that shear rates are elevated in resistance vessels prior to an increase in mean arterial pressure during the development of genetic hypertension. These results suggest that a change in blood rheology may cause a change in peripheral vascular resistance and thus contribute to the pathogenesis of hypertension.
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