期刊
BIOCHEMICAL PHARMACOLOGY
卷 83, 期 6, 页码 695-704出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2011.11.003
关键词
Cardiovascular; Elafin; Elastase; Proteinase-3; Neutrophil
资金
- MRC [G1001339] Funding Source: UKRI
- British Heart Foundation [FS/12/83/29781] Funding Source: Medline
- Medical Research Council [G1001339] Funding Source: Medline
- British Heart Foundation [FS/12/83/29781] Funding Source: researchfish
- Medical Research Council [G1001339] Funding Source: researchfish
Neutrophils and neutrophil-derived elastases play a major role in the regulation of vascular injury and inflammation, such as ischemia-reperfusion injury. Elafin is an endogenous inhibitor of neutrophil-derived elastases with numerous anti-inflammatory functions that include modulation of inflammatory cytokine release as well as innate and adaptive immunity. It is produced by epithelial tissues including the skin and respiratory system that have adapted to respond to the microbial and chemical insults that lead to inflammation. The production of peptides like elafin with multi-faceted anti-inflammatory activity is an important part of this adaptation. Although not directly expressed within the cardiovascular system itself, pre-clinical studies have suggested therapeutic benefit of elafin in cardiovascular disease. The aim of this review is to highlight the role of neutrophil-derived elastases in vascular inflammation and injury. We will discuss the beneficial effects of elafin inhibition of neutrophil elastase and its extended anti-inflammatory activity in pre-clinical models of inflammatory vascular injury. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据