期刊
IMMUNITY
卷 14, 期 5, 页码 617-629出版社
CELL PRESS
DOI: 10.1016/S1074-7613(01)00129-7
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资金
- NCI NIH HHS [CA13148] Funding Source: Medline
- NIAID NIH HHS [R01 AI014782, AI14782, AI07051, T32 AI007051] Funding Source: Medline
The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a natural memory provide a bridge between the very early innate and the later appearing adaptive immune response.
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