期刊
BIOCHEMICAL PHARMACOLOGY
卷 82, 期 10, 页码 1256-1261出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2011.07.068
关键词
p63; Tooth development; Epidermis; FGF; Notch
资金
- Medical Research Council, UK
- Istituto Superiore di Sanita' Alleanza contro il Cancro [ACC12]
- MIUR [RBIP06LCA9_0023]
- AIRC [5471]
- Italian Human ProteomeNet [RBRN07BMCT]
- Min. Salute [Ricerca oncologica 26/07 RF06 (cony. 73), RF07 (cony. 57 e cony. 55)]
- Telethon Melino [GGP09133]
- IDI-IRCCS
- Medical Research Council [MC_U132670600] Funding Source: researchfish
- MRC [MC_U132670600] Funding Source: UKRI
Recent findings have shown that the development of teeth involves a complex sequence of molecular events in which the p53 family member p63 is involved. Indeed, mice lacking p63 do not have teeth and humans bearing mutations in p63 suffer developmental syndromes that affect tooth morphology and number. Several isoforms of p63 have been described: the use of two different promoters produces longer TAp63 isoforms, or shorter, 5' truncated isoforms known as Delta Np63. The 3' end of primary transcripts is then subject to alternative splicing resulting in three additional isoforms: alpha (alpha), beta (beta p) and gamma (gamma). Tooth development relies mainly on the activity of the N-terminally truncated Delta Np63 isoforms. Here we review the experimental evidence for the involvement of Delta Np63 in tooth development through its ability to sustain the molecular signalling that orchestrates epithelial-mesenchymal interaction. (C) 2011 Elsevier Inc. All rights reserved.
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