期刊
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
卷 25, 期 5, 页码 684-687出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00000478-200105000-00019
关键词
hemangioendothelioma; vascular tumors; karyotype; cytogenetics; chromosome
资金
- NCI NIH HHS [P30 CA 36727] Funding Source: Medline
The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes I and 3 It(l:3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma. possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.
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