Aggressive incidents in first-episode psychosis

Background Recent research has reported increased risk of aggressive incidents by individuals with psychotic illness. Aims To examine acts of aggression in first-episode psychosis. Method Subjects with a first-episode psychosis were ascertained from a defined catchment area (Nottingham, UK) and reassessed at 3 years (n = 166) using clinical interview, informants. health care and forensic records. Results Of the subjects,3.6% demonstrated at least one act of serious aggression (defined as weapon use, sexual assault or victim injury) during at least one psychotic episode and 23.5% demonstrated lesser acts of aggression (defined as all other acts of aggression). For all aggressive subjects (33.1%), unemployment (OR=3.6, 95% CI 1.6-8.0), comorbid substance misuse (OR=3.1, CI 1.1-8.8) and symptoms of overactivity at service contact (OR=6.9,CI 2.7-17.8) had independent effects on risk of aggression. Conclusions We confirmed some previously reported demographic and clinical associations with aggression in first-episode psychosis but no relationship with specific psychotic symptoms or diagnostic groups was observed, Declaration of interest Support was received from the National Health Service Executive (Trent Research & Development).