期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 49, 期 1, 页码 84-90出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/eesa.2000.2032
关键词
cadmium; carbaryl; cholinesterase; muscarinic receptor; Oncorhynchus mykiss; swimming speed
Pesticides and heavy metals are common environmental contaminants that can cause neurotoxicity to aquatic organisms, impairing reproduction and survival. Neurotoxic effects of cadmium and carbaryl exposures were estimated in larval rainbow trout (RBT; Oncorhynchus mykiss) using changes in physiological endpoints and correlations with behavioral responses. Following exposures, RBT were videotaped to assess swimming speed. Brain tissue was used to measure cholinesterase (ChE) activity, muscarinic cholinergic receptor (MChR) number, and MChR affinity, ChE activity decreased with increasing concentrations of carbaryl but not of cadmium, MChR were not affected by exposure to either carbaryl or cadmium, Swimming speed correlated with ChE activity in carbaryl-exposed RBT, but no correlation occurred in cadmium-exposed fish, Thus, carbaryl exposure resulted in neurotoxicity reflected by changes in physiological and behavioral parameters measured, while cadmium exposure did not, Correlations between behavior and physiology provide a useful assessment of neurotoxicity. (C) 2001 Academic Press.
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