期刊
TRENDS IN IMMUNOLOGY
卷 22, 期 5, 页码 265-268出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)01888-9
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PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-LP) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
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