期刊
BIOCHEMICAL PHARMACOLOGY
卷 80, 期 12, 页码 1793-1800出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2010.08.024
关键词
Anti-inflammatory; Arachidonic acid; Eicosanoids; Marine natural product; Membrane phospholipids; PLA(2)
资金
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg
- Een Haerz fir Kriibskrank Kanner association
- Action Lions Vaincre le Cancer Luxembourg
- Fonds National de la Recherche Luxembourg
- Televie Luxembourg
- Foundation for Scientific Cooperation, Germany
- Foundation for Scientific Cooperation, Luxemburg
- European Union [215009]
Phospholipases A(2) (PLA(2)s) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLA(2)s have been considered as potential targets in anti-inflammatory drug discovery. Marine natural products are a rich source of bioactive compounds, including PLA(2) inhibitors. Here, we review the properties of marine PLA(2) inhibitors identified since the first discovery of PLA(2) inhibitory activity in the marine natural product manoalide in the mid 1980s. (C) 2010 Elsevier Inc. All rights reserved.
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