期刊
BIOCHEMICAL PHARMACOLOGY
卷 77, 期 3, 页码 285-296出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.09.029
关键词
Catalytic antioxidants; Cell signaling; Drug development; Hydrogen peroxide; Inflammation; Oxidative stress
资金
- NHLBI NIH HHS [R01 HL075523, HL075523, HL084469, R01 HL084469-01A2, R01 HL084469-02, R01 HL084469, R01 HL075523-01, R01 HL075523-02, R01 HL075523-04, R01 HL075523-03] Funding Source: Medline
- NIEHS NIH HHS [U54 ES015678-030002, R01 ES012504-03, U54 ES015678-020002, R01 ES012504-02, U54 ES015678-010002, U54 ES015678, R01 ES012504-01, R01 ES012504-03S1, ES015678, ES012504, R01 ES012504, R01 ES012504-04, R01 ES017582] Funding Source: Medline
Overproduction of the reactive oxygen species (ROS) superoxide (O-2(-)) and hydrogen peroxide (H2O2) are increasingly implicated in human disease and aging. ROS are also being explored as important modulating agents in a number of cell signaling pathways. Earlier work has focused on development of small catalytic scavengers of O-2(-), commonly referred to as superoxide dismutase (SOD) mimetics. Many of these compounds also have substantial abilities to catalytically scavenge H2O2 and peroxynitrite (ONOO-). Peroxides have been increasingly shown to disrupt cell signaling cascades associated with excessive inflammation associated with a wide variety of human diseases. Early studies with enzymatic scavengers like SOD frequently reported little or no beneficial effect in biologic models unless SOD was combined with catalase or a peroxidase. Increasing attention has been devoted to developing catalase or peroxidase mimetics as a way to treat overt inflammation associated with the pathophysiology of many human disorders. This review will focus on recent development of catalytic scavengers of peroxides and their potential use as therapeutic agents for pulmonary, cardiovascular, neurodegenerative and inflammatory disorders. (C) 2008 Elsevier Inc. All rights reserved.
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