期刊
BIOCHEMICAL PHARMACOLOGY
卷 77, 期 8, 页码 1303-1315出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.11.009
关键词
NADPH oxidase; Oxidative stress; Protein tyrosine phosphatases; Reactive oxygen species; Signaling
Abundant evidence leaves no doubt that reactive oxygen species (ROS) are not only inevitable by-products of oxygen metabolism but also play a role in cellular signaling. ROS are produced by a family of NADPH oxidases for signaling purposes and mediate or augment the effects of insulin, growth factors, cytokines and G-protein-coupled receptors. Disturbances of ROS signaling leading to overproduction of these intermediates inflict oxidative damage of cell components in the course of various diseases. Restoration of proper ROS signaling, especially inhibition of cellular sources of ROS, may thus provide new ways of therapy. (C) 2008 Elsevier Inc. All rights reserved.
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