期刊
NUCLEAR MEDICINE AND BIOLOGY
卷 28, 期 4, 页码 435-444出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0969-8051(01)00198-6
关键词
liposomes; technetium-99m; lymphoscintigraphy; HMPAO; sentinel node
资金
- NHLBI NIH HHS [R01-HL53052] Funding Source: Medline
This study investigates the use of [Tc-99m] liposomes for the detection of sentinel lymph nodes. A variety of [Tc-99m] liposome formulations were compared with common lymphoscintigraphic agents including [Tc-99m] regular-sulfur colloid (SC), [Tc-99m] 0.22 mu -filtered-SC, [Tc-99m] reduced heating time 0.22 mu -filtered-SC, and [Tc-99m] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [Tc-99m] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [Tc-99m] filtered SC preparations > [Tc-99m] regular SC > [Tc-99m] liposomes > [Tc-99m] HSA. [Tc-99m] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics. (C) 2001 Elsevier Science Inc. All rights reserved.
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