期刊
BIOCHEMICAL PHARMACOLOGY
卷 78, 期 7, 页码 744-755出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2009.06.004
关键词
Nicotine; Acetylcholine; Midbrain; Nucleus accumbens; Prefrontal cortex
资金
- Biotechnology and Biological Sciences Research Council [BBS/B/15600] Funding Source: Medline
- Parkinson's UK [G-0613] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/B/15600] Funding Source: researchfish
- Parkinson's UK [G-0613] Funding Source: researchfish
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. Thus nAChRs can influence the functions of these three pathways, notably motor control, 'reward' and executive function, respectively. Diverse subtypes of nAChRs have been identified on dopamine cell bodies and terminals as well as on neighbouring afferents and interneurons. Here we review the molecular and cellular mechanisms through which nAChRs exert their influence on these pathways in rodents. (C) 2009 Elsevier Inc. All rights reserved.
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