期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 27, 期 3, 页码 141-150出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1011365401976
关键词
peptide aldehydes; chemical synthesis; enzyme synthesis; protease inhibitors
Various synthetic approaches to modified peptides with the C-terminal aldehyde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Both chemical methods, including solid phase peptide synthesis now widely used, and biocatalytic synthetic methods for obtaining these substances are discussed in detail.
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