期刊
JOURNAL OF NEUROCHEMISTRY
卷 77, 期 3, 页码 896-903出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1471-4159.2001.00292.x
关键词
G protein-coupled receptor; gustation; gustatory system; mouse; Sac locus; taste
In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G rotein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3.
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