期刊
BIOCHEMICAL PHARMACOLOGY
卷 76, 期 11, 页码 1365-1373出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.07.034
关键词
NF-kappa B; Caspase-8; Monocyte differentiation; Apoptosis; Proliferation
资金
- Interuniversitaire Attractiepolen [IAP6/18]
- Fonds voor Wetenschappelijk Onderzoek-Vlaanderen [3G010505]
- Geconcerteerde Onderzoeksacties [01G06B6]
- Instituut voor de aanmoediging van innovatie door Wetenschap en Technologie in Vlaanderen (IWT-Vlaanderen)
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death. CD95 stimulation induces the binding of caspase-8 to a death-inducing signaling complex, leading to its autocatalytic cleavage and the formation of a caspase-8 homodimer, which is subsequently released into the cytosol where it further mediates the apoptotic signaling cascade. Over the past few years, however, several non-apoptotic functions for caspase-8 have been described, indicating that this protease plays a much more diverse role than previously assumed. Here we review the role of caspase-8 in embryonic development, monocyte differentiation, T and B cell proliferation, and the activation of NF-kappa B. (C) 2008 Elsevier Inc. All rights reserved.
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