期刊
BIOCHEMICAL PHARMACOLOGY
卷 76, 期 11, 页码 1340-1351出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.07.031
关键词
Curcumin; Apoptosis; Cancer; Cell signaling pathways; Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
资金
- Televie Luxembourg fellowship
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg
- Een Haerz fir kriibskrank Kanner
- Vaincre le Cancer
- Clayton Foundation for Research
- National Institutes of Health
Apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. Curcumin, a natural compound isolated from the plant Curcuma longa, has chemopreventive properties, which are mainly due to its ability to arrest cell cycle and to induce apoptosis. This article reviews the main effects of curcumin on the different apoptotic signaling pathways involved in curcumin-induced apoptosis of cancer cells, including the intrinsic and extrinsic apoptosis pathways, the NF-kappa B-mediated pathway as well as the PI3K/Akt signaling pathway. This review also focuses on the sensitization of cells to TRAIL-induced apoptosis after curcumin treatment and shows that curcumin enhances the capacity to induce cell death of different chemotherapeutical drugs. (C) 2008 Elsevier Inc. All rights reserved.
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