期刊
BIOCHEMICAL PHARMACOLOGY
卷 76, 期 11, 页码 1451-1458出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.06.023
关键词
CD95; Apoptosis; Tyrosine phosphorylation; PTP; FAP-1; SHP-1
资金
- Concerted Research Action program
- IAP6/18 program
- FNRS
- Centre Anticancereux pres l'Universite de Liege
- FRIA
Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade that culminates in cellular apoptosis. Despite the CD95 receptor does not exhibit any kinase activity by itself, phosphorylation/dephosphorylation events seem important to regulate many aspects of CD95-mediated apoptosis. Here, we try to highlight particularly the importance of protein phosphatases in the modulation of the CD95 system. (C) 2008 Elsevier Inc. All rights reserved.
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