期刊
BIOCHEMICAL PHARMACOLOGY
卷 75, 期 1, 页码 323-333出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2007.06.010
关键词
nicotine; nicotinic; addiction; genetics; mouse; human
资金
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [P50AA015632] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R29DA010455, R01DA014241, P50DA013334, K02DA000436] Funding Source: NIH RePORTER
- NIAAA NIH HHS [P50 AA015632, P50 AA015632-090001, AA15632, P50 AA015632-080001] Funding Source: Medline
- NIDA NIH HHS [DA00436, R29 DA010455-09, R29 DA010455-08, R01 DA014241-05, K02 DA000436-09, DA14241, R01 DA014241, DA13334, K02 DA000436, P50 DA013334, K02 DA000436-08, R29 DA010455, R37 DA014241] Funding Source: Medline
Human twin studies have suggested that there is a substantial genetic component underlying nicotine dependence, ongoing smoking and ability to quit. Similarly, animal studies have identified a number of genes and gene products that are critical for behaviors related to nicotine addiction. Classical genetic approaches, gene association studies and genetic engineering techniques have been used to identify the gene products involved in nicotine dependence. One class of genes involved in nicotine-related behavior is the family of nicotinic acetylcholine receptors (nAChRs). These receptors are the primary targets for nicotine in the brain. Genetic engineering studies in mice have identified a number of subunits that are critical for the ability of nicotine to activate the reward system in the brain, consisting of the dopaminergic cell bodies in the ventral tegmental area and their terminals in the nucleus accumbens and other portions of the mesolimbic system. In this review we will discuss the various lines of evidence suggesting that nAChRs may be involved in smoking behavior, and will review the human and animal studies that have been performed to date examining the genetic basis for nicotine dependence and smoking. (C) 2007 Elsevier Inc. All rights reserved.
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