相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
Patrick J. Lupardus et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers
Stefan N. Constantinescu et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors
Jun Liang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
Angela V. Toms et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year
F. Vincenti et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2012)
Selective JAK1 inhibitor and selective Tyk2 inhibitor patents
Peter Norman
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2
A. V. Purandare et al.
LEUKEMIA (2012)
Targeting IL-17and TH17 cells in chronic inflammation
Pierre Miossec et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
Rajintha M. Bandaranayake et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
William J. Sandborn et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility
Nicolas Couturier et al.
BRAIN (2011)
Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis
B. E. Strober et al.
BRITISH JOURNAL OF DERMATOLOGY (2011)
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
Alessandra Geremia et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Trends in Kinase Selectivity Insights for Target Class-Focused Library Screening
Shana L. Posy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and-23 monoclonal antibody in patients with relapsing-remitting or secondary progressive multiple sclerosis
Timothy L. Vollmer et al.
MULTIPLE SCLEROSIS JOURNAL (2011)
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis et al.
NATURE BIOTECHNOLOGY (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Pseudokinases-remnants of evolution or key allosteric regulators?
Elton Zeqiraj et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
Maria Ban et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2009)
Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?
Erin E. Longbrake et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2009)
The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera
Lisa Pieri et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)
Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis
Akiko Oyamada et al.
JOURNAL OF IMMUNOLOGY (2009)
Novel Tricyclic Inhibitors of IκB Kinase
James Kempson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Periodic, Partial Inhibition of IκB Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis
Kathleen M. Gillooly et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Do enthalpy and entropy distinguish first in class from best in class?
Ernesto Freire
DRUG DISCOVERY TODAY (2008)
Differential regulation of STAT family members by glycogen synthase kinase-3
Eleonore Beurel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T-H-17 responses
Elisabetta Volpe et al.
NATURE IMMUNOLOGY (2008)
Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence
Kotaro Shide et al.
LEUKEMIA RESEARCH (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
The JAK-STAT signaling pathway: Input and output intergration
Peter J. Murray
JOURNAL OF IMMUNOLOGY (2007)
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ
Kumiko Nagashima et al.
BLOOD (2006)
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation - Cross-talk with IGF1 receptor
J Staerk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The V617F JAK2 mutation and the myeloproliferative disorders
MJ Percy et al.
HEMATOLOGICAL ONCOLOGY (2005)
Thermodynamic stability of carbonic anhydrase: Measurements of binding affinity and stoichiometry using ThermoFluor
D Matulis et al.
BIOCHEMISTRY (2005)
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
P Saharinen et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
P Saharinen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7
F Giordanetto et al.
PROTEIN ENGINEERING (2002)
A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis
R Ortmann et al.
JOURNAL OF IMMUNOLOGY (2001)
分享论文
