期刊
BIOCHEMICAL JOURNAL
卷 453, 期 -, 页码 147-151出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20130474
关键词
calcium; endosome; lysosome; nicotinic acid-adenine dinucleotide phosphate (NAADP); two-pore segment channel 1 (TPCN1); trafficking
资金
- Biotechnology and Biological Sciences Research Council [BB/G013721/1, BB/K000942/1]
- BBSRC [BB/K000942/1, BB/G013721/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G013721/1, BB/K000942/1] Funding Source: researchfish
TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of the N-terminal region redirects TPC1 to the ER (endoplasmic reticulum). The introduction of fluorophores at the N-terminus of TPC1 does not affect its subcellular location, but does reversibly abolish NAADP sensitivity. Our results reveal a dual role for the N-terminus in localization and function of TPC1.
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