期刊
JOURNAL OF ANTIBIOTICS
卷 54, 期 5, 页码 405-414出版社
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.54.405
关键词
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RP-1776, a novel cyclic peptide, was isolated from the culture broth of Streptomyces sp. KY11784. RP-1776 selectively inhibited the binding of PDGF BB to the extracellular domain of the PDGF beta -receptor with an IC50 value of 11 +/-6 muM. Detailed binding experiments suggested that RP-1776 directly interacts with PDGF BB. RP-1776 inhibited the phosphorylation of the PDGF beta -receptor induced by PDGF BB. These results suggested that RP-1776 antagonizes the signaling of PDGF BB probably through the inhibition of PDGF BB binding to the PDGF beta -receptor.
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