期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 58, 期 5-6, 页码 728-736出版社
SPRINGER BASEL AG
DOI: 10.1007/PL00000896
关键词
HAT; HDAC; histone acetylation; butyrate; TSA; dietary fiber; leukemia; fragile X syndrome
Differential acetylation of histones and transcription factors plays an important regulatory role in developmental processes, proliferation and differentiation. Aberrant acetylation or deacetylation leads to such diverse disorders as leukemia, epithelial cancers, fragile X syndrome and Rubinstein-Taybi syndrome. The various groups of histone acetyltransferases (CBP/p300, GNAT, MYST, nuclear receptor coactivators and TAFII250) and histone deacetylases are surveyed with regard to their possible or known involvement in cancer progression and human developmental disorders. Current treatment strategies are discussed, which are still mostly limited to histone deacetylase inhibitors such as trichostatin A and butyrate.
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