期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 22, 期 5, 页码 240-246出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01662-X
关键词
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The K+ channel encoded by the human ether-a-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes, HERG encodes the pore-forming subunit of the rapid component of the delayed rectifier K+ channel, I-K(Vr). HERG K+ channels are of considerable pharmaceutical interest as possible therapeutic targets for anti-arrhythmic agents and as the molecular target responsible for the cardiac toxicity of a wide range of pharmaceutical agents. Recent studies of the molecular basis of the promiscuity of HERG K+ channel drug binding has not only started to shed light on this tricky pharmaceutical problem but has also provided further insights into the structure and function of HERG K+ channels.
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