期刊
BIOCHEMICAL JOURNAL
卷 451, 期 -, 页码 25-32出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20121864
关键词
actin; endoplasmic reticulum plasma membrane junctions (ER PM junctions); PANC-1 cells; store-operated Ca2+ entry (SOCE); vinculin
资金
- Wellcome Trust [086738/Z/08/A, 092790/Z/10/Z]
- NIHR (National Institute for Health Research) (U.K.)
- Wellcome Trust [086738/Z/08/A, 092790/Z/10/Z] Funding Source: Wellcome Trust
We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER PM junctions formed near the leading edge of migrating cells (usually within 0.5 mu m of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER PM junctions accompanied the tail withdrawal.
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