期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 113, 期 2, 页码 422-424出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2001.02765.x
关键词
thalidomide; multiple myeloma; soft tissue plasmacytoma
类别
Thalidomide is active in patients with refractory myeloma. Seventeen patients (nine men/eight women, median age 73 years) with multiple myeloma (MM) were treated with thalidomide. Fifteen patients had refractory disease and two untested relapse. The median dose of thalidomide was 500 mg (range, 200-800 mg). Nine of the 17 patients (53%) responded. The response rate was significantly higher in patients with no extramedullary disease than in those with soft tissue masses (75% CI: 43-95% versus 0%: P = 001)). Of note, no decrease in the size of soft tissue plasmacytomas was observed in all the five patients who had extramedullary involvement. This data suggests that the mechanism of action and effectiveness of thalidomide might depend on the site of the tumour cells.
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