期刊
BIOCHEMICAL JOURNAL
卷 443, 期 -, 页码 3-12出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20111943
关键词
anaphase-promoting complex (APC); Cdhl; glycolysis; pentose phosphate pathway; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3)
资金
- FEDER (European Regional Development Fund)
- Ministerio de Ciencia e Innovacion [SAF2010-20008, CSD2007-00020]
- Institute de Salud Carlos III [PS09/0366, RD06/0026/1008]
- Junta de Castilla y Leon [GREX206]
Oxidative and nitrosative stress underlie the pathogenesis of a broad range of human diseases, in particular neurodegenerative disorders. Within the brain, neurons are the cells most vulnerable to excess reactive oxygen and nitrogen species; their survival relies on the antioxidant protection promoted by neighbouring astrocytes. However, neurons are also intrinsically equipped with a biochemical mechanism that links glucose metabolism to antioxidant defence. Neurons actively metabolize glucose through the pentose phosphate pathway, which maintains the antioxidant glutathione in its reduced state, hence exerting neuroprotection. This process is tightly controlled by a key glycolysis-promoting enzyme and is dependent on an appropriate supply of energy substrates from astrocytes. Thus brain bioenergetic and antioxidant defence is coupled between neurons and astrocytes. A better understanding of the regulation of this intercellular coupling should be important for identifying novel targets for future therapeutic interventions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据