期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 47, 期 5, 页码 651-654出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/47.5.651
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资金
- NIAID NIH HHS [AI-21150] Funding Source: Medline
During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded afflux pump system, but remained susceptible to Triton X-100, We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.
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