期刊
BIOCHEMICAL JOURNAL
卷 438, 期 -, 页码 11-23出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20102152
关键词
cell differentiation; embryonic stem cell (ESC); kinase inhibitor; leukaemia inhibitory factor (LIF); protein phosphorylation; signal transducer and activator of transcription 3 (STAT3)
资金
- Richard M. Schulze Family Foundation
- National Institutes of Health [R01 DK082430]
LlF (leukaemia inhibitory factor) is a key cytokine for maintaining self-renewal and pluripotency of mESCs (mouse embryonic stern cells). Upon binding to the LIF receptor, LIF activates three major intracellular signalling pathways: the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3), PI3K (phosphoinositide 3-kinase)/AKT and SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase 2]/MAPK (rnitogen-activated protein kinase) pathways. These pathways converge to orchestrate the gene expression pattern specific to mESCs. Among the many signalling events downstream of the LIF receptor, activation and DNA binding of the transcription factor STAT3 plays a central role in transducing LIF's functions. The fundamental role of LIF for pluripotency was highlighted further by the discovery that LIE accelerates the conversion of epiblast-derived stem cells into a more fully pluripotent state. In the present review, we provide an overview of the three major LIF signalling pathways, the molecules that interact with STAT3 and the current interpretations of the roles of LIP in pluripotency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据