相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts
Juan S. Ramirez-Lugo et al.
CELL CYCLE (2011)
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress
Y. Liu et al.
CELL DEATH AND DIFFERENTIATION (2011)
Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control
Charles Chung Yun Leung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis
Navjotsingh Pabla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
CEP152 is a genome maintenance protein disrupted in Seckel syndrome
Ersan Kalay et al.
NATURE GENETICS (2011)
Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication
Akiko Kumagai et al.
CELL (2010)
FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
Sarah Luke-Glaser et al.
EMBO JOURNAL (2010)
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint
Rachele Cescutti et al.
EMBO JOURNAL (2010)
ATR activation and replication fork restart are defective in FANCM-deficient cells
Rebekka A. Schwab et al.
EMBO JOURNAL (2010)
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response
David S. Yu et al.
EMBO REPORTS (2010)
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
Hiroyuki Takai et al.
GENES & DEVELOPMENT (2010)
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
Kristen E. Hurov et al.
GENES & DEVELOPMENT (2010)
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
Karim Labib
GENES & DEVELOPMENT (2010)
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
Yiyong Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Transcription Elongation Factor Bur1-Bur2 Interacts with Replication Protein A and Maintains Genome Stability during Replication Stress
Emanuel Clausing et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
Takeshi Kaizuka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
Xin Quan Ge et al.
JOURNAL OF CELL BIOLOGY (2010)
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells
Kazumasa Yoshida et al.
JOURNAL OF CELL SCIENCE (2010)
Novel CENPJ mutation causes Seckel syndrome
Mohammed S. Al-Dosari et al.
JOURNAL OF MEDICAL GENETICS (2010)
ATR and ATRIP Are Recruited to Herpes Simplex Virus Type 1 Replication Compartments Even though ATR Signaling Is Disabled
Kareem N. Mohni et al.
JOURNAL OF VIROLOGY (2010)
Molecular Architecture of the Human Prp19/CDC5L Complex
Michael Grote et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability
Zuzana Horejsi et al.
MOLECULAR CELL (2010)
Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7
John C. W. Randell et al.
MOLECULAR CELL (2010)
MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM
Thiyam Ramsing Singh et al.
MOLECULAR CELL (2010)
BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control
Zihua Gong et al.
MOLECULAR CELL (2010)
A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability
Zhijiang Yan et al.
MOLECULAR CELL (2010)
The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response
Min Huang et al.
MOLECULAR CELL (2010)
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
Bancinyane L. Sibanda et al.
NATURE (2010)
An unprecedented nucleic acid capture mechanism for excision of DNA damage
Emily H. Rubinson et al.
NATURE (2010)
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
Han Liu et al.
NATURE (2010)
Maintaining genome stability at the replication fork
Dana Branzei et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
DNA resection in eukaryotes: deciding how to fix the break
Pablo Huertas
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
Jun-Hyuk Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing
Judith Pirngruber et al.
CELL CYCLE (2009)
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity
Yen-Ru Pan et al.
CELL CYCLE (2009)
Eukaryotic DNA replication control: Lock and load, then fire
Dirk Remus et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
Travis H. Stracker et al.
DNA REPAIR (2009)
Common mechanisms of PIKK regulation
Courtney A. Lovejoy et al.
DNA REPAIR (2009)
Emerging common themes in regulation of PIKKs and PI3Ks
Harri Lempiaeinen et al.
EMBO JOURNAL (2009)
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint
Nianxiang Zhang et al.
EMBO REPORTS (2009)
TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
Shan Yan et al.
JOURNAL OF CELL BIOLOGY (2009)
ATR Mutation in Endometrioid Endometrial Cancer Is Associated With Poor Clinical Outcomes
Israel Zighelboim et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ATM
Hae Yong Yoo et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms
Vasundhara M. Navadgi-Patil et al.
MOLECULAR CELL (2009)
A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
Renee D. Paulsen et al.
MOLECULAR CELL (2009)
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
Jun-Hyuk Choi et al.
NUCLEIC ACIDS RESEARCH (2009)
Functional genomic screens identify CINP as a genome maintenance protein
Courtney A. Lovejoy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
Jung Min Kim et al.
BLOOD (2008)
Biphasic MLL takes helm at cell cycle control - Implications in human mixed lineage leukemia
Han Liu et al.
CELL CYCLE (2008)
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
Gaetano Romano et al.
CELL CYCLE (2008)
Plx1 is required for chromosomal DNA replication under stressful conditions
Kristina Trenz et al.
EMBO JOURNAL (2008)
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
Daniel A. Mordes et al.
GENES & DEVELOPMENT (2008)
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
Sudhakar Sivasubramaniam et al.
GENES & DEVELOPMENT (2008)
Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase
Vasundhara M. Navadgi-Patil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
Xin Xu et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex
Spencer J. Collis et al.
MOLECULAR CELL (2008)
Genome instability: a mechanistic view of its causes and consequences
Andres Aguilera et al.
NATURE REVIEWS GENETICS (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Dpb11 activates the Mec1-Ddc2 complex
Daniel A. Mordes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
Arkaitz Ibarra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
An oncogene-induced DNA damage model for cancer development
Thanos D. Halazonetis et al.
SCIENCE (2008)
Cryo-EM structure of the DNA-Dependent protein kinase catalytic subunit at subnanometer resolution reveals α helices and insight into DNA binding
Dewight R. Williams et al.
STRUCTURE (2008)
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Elen Griffith et al.
NATURE GENETICS (2008)
TeI2 regulates the stability of PI3K-related protein kinases
Hiroyuki Takai et al.
CELL (2007)
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
Xin Quan Ge et al.
GENES & DEVELOPMENT (2007)
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
Yingli Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Cep164, a novel centriole appendage protein required for primary cilium formation
Susanne Graser et al.
JOURNAL OF CELL BIOLOGY (2007)
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution:: a critical regulatory circuit lost in leukemogenic MLL fusions
Han Liu et al.
GENES & DEVELOPMENT (2007)
The Rad9-Hus1-Rad1 checkpoint interaction of TopBP1 with ATR
Joon Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cyclin-dependent kinase 2-dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage
Jeremy S. Myers et al.
CANCER RESEARCH (2007)
Bid plays a role in the DNA damage response
Sandra S. Zinkel et al.
CELL (2007)
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
Sinny Delacroix et al.
GENES & DEVELOPMENT (2007)
Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin
Damien Hermand et al.
MOLECULAR CELL (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka et al.
SCIENCE (2007)
Function of a conserved checkpoint recruitment domain in ATRIP proteins
Heather L. Ball et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM
Alberto Ciccia et al.
MOLECULAR CELL (2007)
Replication fork barriers: pausing for a break or stalling for time?
Karim Labib et al.
EMBO REPORTS (2007)
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
Jerzy Majka et al.
MOLECULAR CELL (2006)
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova et al.
NATURE (2006)
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
Anna M. Woodward et al.
JOURNAL OF CELL BIOLOGY (2006)
ATR kinase activation mediated by MutSα and MutLα in response to cytotoxic O6-methylguanine adducts
Ken-Ichi Yoshioka et al.
MOLECULAR CELL (2006)
TopBP1 activates the ATR-ATRIP complex
A Kumagai et al.
CELL (2006)
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks
E Itakura et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
HL Ball et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
AR Meetei et al.
NATURE GENETICS (2005)
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
G Mosedale et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Proapoptotic BID is an ATM effector in the DNA-damage response
I Kamer et al.
CELL (2005)
Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance
KA Lewis et al.
CANCER RESEARCH (2005)
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
HL Ball et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
TS Byun et al.
GENES & DEVELOPMENT (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
VG Gorgoulis et al.
NATURE (2005)
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
A Traven et al.
BIOESSAYS (2005)
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation
M Oehlmann et al.
JOURNAL OF CELL BIOLOGY (2004)
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
K Ünsal-Kaçmaz et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
Y Fang et al.
EMBO JOURNAL (2004)
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
HY Yoo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
D Cortez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
A Kumagai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mismatch repair-dependent G2 checkpoint induced by low doses Of SN1 type methylating agents requires the ATR kinase
L Stojic et al.
GENES & DEVELOPMENT (2004)
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BCRT domains of Rad4TOPBP1
K Furuya et al.
GENES & DEVELOPMENT (2004)
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
Y Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Biochemical characterization of DNA damage checkpoint complexes:: Clamp loader and clamp complexes with specificity for 5′ recessed DNA
V Ellison et al.
PLOS BIOLOGY (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
M O'Driscoll et al.
NATURE GENETICS (2003)
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
VP Bermudez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
L Clay-Farrace et al.
EMBO JOURNAL (2003)
Preferential binding of ATR protein to UV-damaged DNA
K Ünsal-Kaçmaz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p
H Murakami et al.
NATURE CELL BIOLOGY (2002)
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
L Zou et al.
GENES & DEVELOPMENT (2002)
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
K Yamane et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
ATR and ATRIP: Partners in checkpoint signaling
D Cortez et al.
SCIENCE (2001)
Recruitment of Mec1 and Dcd1 checkpoint proteins to double-strand breaks through distinct mechanisms
T Kondo et al.
SCIENCE (2001)
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
JA Tercero et al.
NATURE (2001)
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
H Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
LCD1:: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
J Rouse et al.
EMBO JOURNAL (2000)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
A de Klein et al.
CURRENT BIOLOGY (2000)
分享论文
