期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 26, 期 5, 页码 291-297出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(01)01804-7
关键词
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Eukaryotic cells, whether free-living, single-celled microbes or components of complex metazoa. can sense environmental cues through specialized seven-transmembrane (7-TM) receptors (also called heptahelical or G-protein-coupled receptors). 7-TM receptors detect 'inputs' such as light. peptide hormones, neurotransmitters, pheromones, odorants, morphogens and chemoattractants, linking extracellular stimuli to intracellular signaling networks via heterotrimeric G proteins. Recently, this obligatory paradigm has been challenged. A growing body of evidence indicates that 7-TM receptors can also transmit extracellular signals through mechanisms that function independently of G-protein coupling. This review discusses pathways and protein interactions for 7-TM receptors signaling 'at zero G' in Dictyostelium acid mammalian cells.
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