期刊
BIOCHEMICAL JOURNAL
卷 430, 期 -, 页码 191-198出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20100427
关键词
dephosphorylation; phosphorylation; protein phosphatase; Smad; transforming growth factor-beta (TGF-beta) signalling
资金
- China's Fundamental Research Funds for National/Central Universities
- National Institutes of Health [R01AR053591, R01GM063773, R01CA108454]
- NATIONAL CANCER INSTITUTE [R01CA108454] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR053591] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063773] Funding Source: NIH RePORTER
Tight regulation of TGF-beta (transforming growth factor-beta) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-beta superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-beta signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-beta signalling and the essential role of protein phosphatases in this process.
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